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The application of HP-beta-CD in natural drug preparation---Volatile oil

Volatile oil is the general term for a kind of oily liquid with aromatic smell.It can volatilize spontaneously at normal temperature, insoluble in water, and the contact with air and light will gradually oxidize.Antiviral oral liquid of pogostemon cablin in the prescription, forsythia, stone calamus, turmeric for ingredients, rich in volatile oil was prepared by the four kinds of reflux extraction of volatile oil of HP - beta - CD inclusion compound, and the stability of the inclusion compound was investigated.The results showed that the anti-photolysis, thermal stability and humidity stability of volatile oil were significantly higher than that of the mixture.Through accelerated test method, the 3 batches of samples in the temperature of the improved process (40 + 2) ℃, relative humidity conditions for (75 + 5) % 3 months, compared with 0 month, naphtha average loss percentage is 19.18%, while product naphtha average percentage loss in the improved process is not as high as 97.25%.It contains triterpenes and volatile oils, which are used in the treatment of allergic rhinitis, but the active ingredient is volatile in the process of storage and use.In this paper, the non-herbivorous oil of CO2 supercritical extraction was carried out by hp-a-cd, and it was further made into sprayers to mask the odor of drugs and improve the compliance of patients.Preparation of asarone HP - beta - CD inclusion compound, and compare the rabbit nasal respectively perfusion asarone HP - beta - CD solution and the bioavailability of asarone water saturated solution agent, the results show that the formation of inclusion compound, after rabbit nasal cavity perfusion, rabbit blood, rhinencephalon, turbinate, brain uptake were higher than water saturated solution, the bioavailability of asarone was improved.

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