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The application of Hydroxypropyl Beta Cyclodextrin in Oral preparations

The application of Hydroxypropyl Beta Cyclodextrin in Oral preparations

The inclusion compound of Hydroxypropyl Beta Cyclodextrin (HPBCD) and insoluble drugs can increase the solubility and dissolution rate of drugs and improve the oral bioavailability.After Ursacol was prepared from Ursacol, the disintegration time was the same as that of Ursacol, but the dissolution was fast and complete. The oral bioavailability and peak concentration of healthy subjects were more than twice that of the marketed products.The absolute bioavailability of iso-dimensional A acid HPBCD inclusion solution in SD rats increased from 7.7% in suspension to 22.1%.


HPBCD can also improve the stability of oral drugs in vivo.4mmol/L can delay the degradation of rutin in the intestinal homogenate of rats, and the bioavailability of oral rutin -HPBCD inclusion compound tablets in dogs is three times higher than that of commercially available rutin tablets.Progesterone, testosterone and estradiol are made into sublingual tablets to avoid first-pass effects.

HPBCD can also be used as a pore-causing agent in oral slow-release agents.The bioavailability of nifedipine bilayer tablets made from one part of HPBCD and three parts of HPC as the framework is similar to that of Adalat, a commercially marketed nifedipine sustained-release preparation, but the blood concentration is more stable.

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