The characteristics of Hydroxypropyl Betadex
The characteristics of Hydroxypropyl Beta Cyclodextrin
The saturation rate of Hydroxypropyl Beta Cyclodextrin (HPBCD) is generally not high, and many excipients such as surfactants, lipids, organic solvents, buffer salts and preservatives also reduce the inclusion rate.But water-soluble polymers such as polyvinylpyrrolidone (PVP), sodium carboxy methyl cellulose (CMC Na) and hydroxypropyl methyl cellulose (HPMC) can pass the stability of drugs - HPBCD clathrate and increase HPBCD water-soluble to improve to a lot of fat soluble rate of inclusion of guest molecules.
Medical HPBCD is cheap and can be produced in large scale. Therefore, the listed products are mixtures of various isomers, whose properties are expressed by average substitution degree.The higher the average degree of substitution, the lower the coupling force with the drug.
HPBCD white amorphous powder, alkali, heat and light stability, can tolerate 10 d 80 ℃ and 4500 lx illumination, aqueous solution can be autoclave.It is easy to absorb moisture under high humidity (rh92.5%) and unstable to strong acid.