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Application Of P-butyl Ether-betamethasone Sodium Salt In Puerarin

Puerarin (Puerarin) is one of the main active constituents extracted from lobata and Gangettogen of leguminous plants, the chemical called 4 ', 7-two hydroxy-8-β-d-isoflavone, for reducing blood pressure and myocardial oxygen consumption, antiarrhythmic, limited myocardial infarction range and other diseases have a good clinical efficacy mainly for the treatment of coronary heart disease, myocardial infarction, hypertension, sudden deafness and other diseases.

Because the Puerarin in vivo elimination fast, not easy to accumulate, the water-soluble small, directly affected its bioavailability and the curative effect.

The sulfonated butyl ether-β-cyclodextrin (SBE-Β-CD) is a sulfonated alkyl ether derivative of β-cyclodextrin (Β-CD), which has the advantages of good water-solubility, low renal toxicity and small hemolysis, and is a kind of medicinal excipients with excellent properties. has received extensive attention in the field of medicine. At present, it has certain application in injection, oral preparation and local drug delivery agent. SBE-Β-CD has a good solubilization effect on insoluble drugs.

Recently, it has been found that Puerarin can be made into-SBE-Β-CD inclusions, which significantly improve the solubility, dissolution and stability of Puerarin, and provide an effective way to improve the absorption state and bioavailability of Puerarin in vivo.

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